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High-Intensity Laser and Photodynamic Therapy as a Treatment for Recurrent Herpes Labialis

Marotti J, Sperandio FF, Fregnani ER, Aranha AC, de Freitas PM, de Paula Eduardo C.
1 Department of Prosthodontics/Special Laboratory of Lasers in Dentistry (LELO), School of Dentistry, University of São Paulo
Photomed Laser Surg. 2009 Oct 12
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Abstract Objective

The aim of this study was to report the treatment of recurrent herpes labialis (RHL) using a high-intensity laser or methylene blue (MB)-mediated photodynamic therapy (PDT) in combination with low-level laser therapy (LLLT).

Materials and Methods

Four clinical cases of patients diagnosed with RHL are described in this report. Two patients were subjected to high-intensity laser therapy (HILT) followed by LLLT, and two patients received MB-mediated PDT, again followed by LLLT. LLLT was conducted at 24, 48, 72 h, and 7 d after HILT or PDT. Patients were followed up after 6 mo.

Results

Throughout the follow-up period, all patients reported pain relief and did not show any signs or symptoms of RHL. A favorable healing process was observed in all cases. None of the patients reported pain as a consequence of the treatment.

Conclusion

These results suggest that HILT and MB-mediated PDT, in combination with LLLT, may constitute a benefit when treating vesicles in RHL.