Sub Pages:

High-Intensity Laser and Photodynamic Therapy as a Treatment for Recurrent Herpes Labialis

Marotti J, Sperandio FF, Fregnani ER, Aranha AC, de Freitas PM, de Paula Eduardo C.
1 Department of Prosthodontics/Special Laboratory of Lasers in Dentistry (LELO), School of Dentistry, University of São Paulo
Photomed Laser Surg. 2009 Oct 12

Abstract Objective

The aim of this study was to report the treatment of recurrent herpes labialis (RHL) using a high-intensity laser or methylene blue (MB)-mediated photodynamic therapy (PDT) in combination with low-level laser therapy (LLLT).

Materials and Methods

Four clinical cases of patients diagnosed with RHL are described in this report. Two patients were subjected to high-intensity laser therapy (HILT) followed by LLLT, and two patients received MB-mediated PDT, again followed by LLLT. LLLT was conducted at 24, 48, 72 h, and 7 d after HILT or PDT. Patients were followed up after 6 mo.


Throughout the follow-up period, all patients reported pain relief and did not show any signs or symptoms of RHL. A favorable healing process was observed in all cases. None of the patients reported pain as a consequence of the treatment.


These results suggest that HILT and MB-mediated PDT, in combination with LLLT, may constitute a benefit when treating vesicles in RHL.